Weight Loss & Metabolic
MOTS-c
Also known as: Mitochondrial open reading frame of the 12S rRNA-c
A 16-amino-acid peptide encoded in the body's mitochondrial DNA, studied mainly in mice for effects on metabolism and insulin sensitivity.
Overview
MOTS-c is one of a small group of peptides encoded in mitochondrial DNA, the genetic material found in the cell's energy-producing structures, rather than in the cell nucleus. Its discovery shifted how researchers think about mitochondria as signaling organs.
What the research has looked at
In mice, MOTS-c treatment was reported to improve insulin sensitivity and to protect against weight gain on a high-fat diet. Other studies have examined its levels in humans, including changes with exercise and age.
What we do not know
- Most findings come from mice, and effects in people have not been shown in controlled trials.
- The exact mechanisms are still being worked out.
- The safety and effects of long-term use in humans are unknown.
Regulatory context
MOTS-c is not an approved medicine.
Related pages
See the Peptide A-Z for other compounds studied for metabolic effects.
References & further reading
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
Educational reference only. Not medical advice. This page does not recommend or describe human use, dosing or sourcing.